Best Frontline Plus Flea Treatment

Updated for 2023

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CATS
FRONTLINE Plus For Cats and Kittens Flea and Tick Treatment, 3 Doses
$42.88
What We Like

Ideal for those who want both flea and tick prevention and treatment.

SMALL DOGS
FRONTLINE Plus for Dogs and Puppies (Dogs 8 weeks or older 5 to 22 lbs.) Flea and Tick Treatment, 6…
$75.98
What We Like

Worth trying for those who want a well-known treatment for both fleas and ticks.

MEDIUM DOGS
FRONTLINE Plus for Dogs Flea and Tick Treatment (Medium Dog, 23-44 lbs.) 3 Doses (Blue Box)
$40.99
What We Like

Ideal for those who want a reputable treatment for both fleas and ticks in a seasonal trial size.

How We Found the Best Frontline Plus Flea Treatments

7 Reviewers

21 Products Considered

8 Hours of Research

5 Products Reviewed

3 Top Picks

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Best Frontline Plus Flea Treatment

Ectoparasites are organisms that live on an animal as a parasite on their skin or in their fur. Some of the more common ectoparasites are fleas and ticks. Fleas and ticks are not just an annoyance to your home or your pet. These pests post serious health risks to your beloved pet and yourself. So, if you’ve skipped treating your animal with flea and tick preventative, you might want to consider the tradeoffs of avoiding flea treatments.

First, we’ve compared Frontline’s best flea and tick treatments for your particular pet. This buyer’s guide should aid you in finding the best preventative medication to keep your animals safe. Outside, fleas like to live in shady, protected areas. These are often areas pets like to rest, so, it’s especially important to keep your dog or cat on flea medication if they are outside often. Read on to find out why fleas and ticks are not only a nuisance but can actually be deadly if not treated.

BEST FOR FELINES

Frontline Plus for Cats and Kittens

$42.88 Amazon Prime
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Last update on 2024-03-01 / Affiliate links / Images from Amazon Product Advertising API

Features & Specs
  • Provides fast-acting treatment of fleas
  • Approved for use on cats and kittens eight weeks or older
  • Kills adult fleas as well as their eggs and larvae
  • Kills ticks that can spread Lyme disease and Rocky Mountain Spotted Fever
  • Effective for 30 days
  • Six-dose supply will last half a year
  • Under $65 for a six-month supply
  • .50 ml applicators
  • Active ingredients are fipronil and (S)-methoprene

The active ingredients in Frontline Plus for Cats and Kittens are fipronil and (S)-methoprene. One is to kill fleas and ticks in their adult form, and the other is to kill the eggs and larvae.

With this product, you simply cut where the package indicates and apply onto the skin of your cat above the shoulder blade area near the base of the neck. Be sure you wear gloves or wash your hands immediately after applying medication to your pet.

BEST FOR SMALL CANINES

Frontline Plus for Dogs (Small Dog 5-22 Pounds)

$75.98 Amazon Prime
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Last update on 2024-03-01 / Affiliate links / Images from Amazon Product Advertising API

Features & Specs
  • Kills insects on pets quickly
  • Approved for use on dogs and puppies, 5 to22 pounds
  • Kills ticks, including those that may transmit Lyme disease
  • Also assists in the control of sarcoptic mange infestations
  • Six-dose supply lasts you half a year
  • Under $65 for a six-month supply
  • .67 ml applicators
  • Active ingredients are fipronil and (S)-methoprene

Frontline has been recommended by veterinarians for roughly 20 years. This product for small dogs works quickly and comes with an easy snap-open plastic vile. While wearing gloves, just open the package and apply the product at the base of your dog’s neck on the skin.

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BEST FOR MEDIUM SIZED DOGS

Frontline Plus for Dogs (Medium Dog 23-44 pounds)

$40.99 Amazon Prime
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Last update on 2024-03-01 / Affiliate links / Images from Amazon Product Advertising API

Features & Specs
  • Kills insects on pets quickly
  • Approved for use on dogs and puppies, 5 to22 pounds
  • Kills ticks, including those that may transmit Lyme disease
  • Also assists in the control of sarcoptic mange infestations
  • Six-dose supply lasts you half a year
  • Under $65 for a six-month supply
  • .67 ml applicators
  • Active ingredients are fipronil and (S)-methoprene

Frontline is one of the top flea and tick preventions recommended by veterinarians for almost two decades. This flea prevention for medium-sized dogs is ideal for canines between 23 and 44 pounds. This product works fast and comes with an easy snap-open plastic vile. Apply this product at the base of your dog’s neck on the skin. It’s best to wear gloves or wash your hands immediately after applying this flea control to your pet, as it’s not designed specifically for humans.

BEST FOR LARGE CANINES

Frontline Plus for Dogs (Large Dog 45 to 88 pounds)

$78.98 Amazon Prime
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Last update on 2024-03-01 / Affiliate links / Images from Amazon Product Advertising API

Features & Specs
  • Approved for use on canines ranging from 45 to 88 pounds
  • Kills fleas in all stages as well as ticks
  • Also aids in the control of sarcoptic mange infestations
  • Around $67 for a six-month supply
  • 2.68 ml applicators
  • Active ingredients are fipronil and (S)-methoprene

Frontline has been among of the top flea and tick preventions recommended by veterinarians for almost 20 years. Even for larger dogs, this flea prevention can treat large dogs up to 88 pounds. This product works fast and comes with an easy snap-open plastic vile. Apply this product at the base of your dog’s neck on the skin.

Reviews are a bit mixed. Some animals have negative reactions. Although most pets seemed to handle it fine. In some areas, customers claim Frontline used to work for them and suddenly stopped. So, fleas may be turning resistant, or some online outlets are selling counterfeit products. Otherwise, this is a very highly rated product.

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BEST FOR XL CANINES

Frontline Plus for Dogs Extra Large Dog (89 to 132 pounds)

$40.99 Amazon Prime
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Last update on 2024-03-01 / Affiliate links / Images from Amazon Product Advertising API

Features & Specs
  • Approved for use on canines ranging from 89 to 132 pounds
  • Kills fleas in all stages as well as ticks
  • Also aids in the control of sarcoptic mange infestations
  • Around $40 for a three-month supply
  • 4.02 ml applicators
  • Active ingredients are fipronil and (S)-methoprene

Even for the biggest dogs, this XL dog flea prevention is effective for canines breeds such as Great Dane and St. Bernard up to 132 pounds. This product works fast and comes with an easy snap-open plastic vile. Apply this product at the base of your dog’s neck on the skin. Larger dogs have a lot of fur for fleas to hide in, so it’s extra important to be sure they’re protected.

Reviews are a bit mixed. Some animals have negative reactions to medications, and this is no exception. Although most pets seemed to handle it fine. In particular regions, customers claim Frontline used to work for them and abruptly stopped. So, fleas may be turning resistant, or some online outlets are selling phony products. Otherwise, this is a very highly rated product.

Trying to get rid of fleas for good?

Get a FREE Quote & BEST PRICE from a local exterminator

(866) 470-1609

Available Next Day

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How It Works

Frontline Plus contains fipronil. Fipronil is a broad-spectrum insecticide that also works as a slow-acting poison that kills fleas and ticks. Frontline also contains S-Methoprene, an insect growth regulator that works to eradicate the eggs and larvae. These ingredients are stored in your pet’s sebaceous glands and are emitted out of the hair follicles to the coat their fur with long-lasting, waterproof protection.

The Risk Ticks and Preventing Them

Ticks attach to animals via their mouths into your pet skin. There are several diseases associated with ticks, not only for your pet but that also pose a risk for you. In rare situations, some female ticks can cause paralysis in canines due to a toxin they produce while they feed.

Rocky Mountain Spotted Fever is another serious illness that is also transferable to humans and animals through tick bites. Some symptoms are lethargy and, of course, fever. Most people who get ill with RMSF will feel feverish, have headaches, and spotted rashes. RMSF is potentially deadly if not treated early with proper antibiotics.

More commonly, ticks carry Lyme disease. Lyme disease is produced by the bacterium Borrelia burgdorferi and is spread to humans through bites from infected black-legged ticks. Symptoms most often include fever, severe fatigue, headache, and a skin rash. If left untreated, Lyme disease can spread to your joints, heart, and your nervous system. Lyme disease has some symptoms including arthritis, swelling of your pet’s joints, and lameness.

While it is difficult to prevent exposure to ticks especially in certain regions. Using a preventative medication is one of the best ways to keep ticks off your dog or cat. Be sure to check your animal thoroughly for any attached ticks after outdoor activities such as walking and hiking. Also, remember to check your own body using a mirror to make sure you are clear of ticks after a hike through tick-prone areas.

Especially in certain regions, ticks can be a problem even in your own backyard. Keeping a buffer between your lawn and a forested area if you live near one can also help prevent tick infestation in your yard. Gravel or mulch can be used as a type of mode between woodlands to minimize tick migration into your lawn. Ticks often live in high grassy or weeded areas and forested areas.

Fleas and Their Signs

Fleas are generally no larger than 1/8 of an inch long at adult size. So, it can be difficult to see some of the characteristics used to identify them. However, these reddish-brown, wingless insects pose several health risks beyond an itching sensation.

Fleabites entail of a small reddened spot encircled by a red halo, typically without much swelling. They usually cause an itching sensation but can become progressively irritating to people or animals with sensitive skin.

Some of the first signs of fleas are your pets repeatedly chewing or scratching themselves. On occasion, you can see small brown fleas moving quickly through the animal fur. Consistent scratching can result in patches of hair loss or red and skin.

Risks of Fleas

Research shows fleas are capable of spreading a typhus disease in humans. The symptoms are like to murine typhus but not as severe and include headaches, fever, chills, vomiting, and a rash. If the fleas fed off of rats, in some areas, they even pose the threat of plague.

Some people and pets experience allergic dermatitis from fleabites. Allergic Dermatitis is characterized by severe itching, hair or fur loss, irritated skin, and secondary infection. It only takes one single bite to start an allergic reaction Itching can last up to five days after the bite occurred.

Once fleas infest your home, getting rid of them will require a vigilant program that can be exhausting. Ridding a house of fleas necessitates a protocol that includes vacuuming, high-temp washing all clothes and sheets, eradicating fleas on pets with various medicines and shampoos, and possibly treating shaded outdoor locations where your pets often play or rest. Preventing fleas with a product like Frontline is definitely more manageable than getting rid of an infestation.

Trying to get rid of fleas for good?

Get a FREE Quote & BEST PRICE from a local exterminator

(866) 470-1609

Available Next Day

No Obligation Assessment

Guarantee Results